The three cases presented here demonstrate a wellcircumscribed tumor, which showed a cystic and solid, or the pure solid mass. Basal cell adenoma is a benign epithelial salivary gland tumor that appears to have unique histologic characteristics. The patient was a 72yearold japanese male, who had noticed swelling of the left parotid region 21 years ago. More than 80% of basal cell adenomas arise in the major salivary glands, mostly the parotid gland. Basal cell adenoma is a rare, lowgrade benign salivary gland neoplasm the most common involved site is the parotid gland, however other possible sites include the submandibular gland, minor salivary glands of upper lip, buccal mucosa, palate and nasal septum it appears as a slowgrowing, firm and mobile mass. Basal cell adenoma was classified as part of the category of monomorphic adenomas, which was. Salivary gland tumors are uncommon and constitute about 2. Treatment is by surgical excision with a margin of healthy tissue. Histopathologically, bca is composed of basaloid cells and can be classified into solid with most common type, trabecular, tubular, and membranous types.
Lee dk1, chung kw, baek ch, jeong hs, ko yh, et al. Among the benign tumours of the parotid gland, basal cell adenoma bca is far less common than pleomorphic adenoma pa. It is composed of monomorphic basaloid cells without invasive potentials seen in adenoid cystic carcinoma or the myxochondroid stroma seen in pleomorphic adenoma pa. Basal cell adenocarcinoma of minor salivary glands archives of. Basal cell adenoma bca is a rare benign tumour that has unique histological characteristics and primarily arises in the parotid glands. Basal cell adenoma may rarely transform 4% to malignant conditions like basal cell adenocarcinoma,adenoid cystic carcinoma,salivary duct carcinoma,or adenocarcinoma nos. Clinically, bca is usually a slowgrowing, asymptomatic, and freely movable mass. About 60% of the tumor was made up of cribriform and trabecular tissue composed of basaloid cells. Carcinoma ex basal cell adenoma of the parotid gland. Approximately 80% originate in the parotid gland and they are rarely present in the submandibular gland.
The cribriform pattern of the basal cell adenocarcinoma with. Batsakis is credited with reporting the first case in the american literature in 1972 and suggested that the intercalated duct or reserve cell is the histogenic source of basal cell adenoma. Salivary gland basal cell and canalicular adenomas. Basal cell adenoma is a rare benign salivary gland epithelial tumor, usually involving the parotid gland. Basal cell adenoma misdiagnosed as an adenoid cystic. Celal ertug etimesgut state hospital ear nose and throat department ankara, turkey. The clinical, gross, and microscopic features appear distinctive enough to justify separation of this tumor from mixed tumors pleomorphic adenomas of the salivary glands. The tumor is mostly seen in elderly adults the tissue biopsy of the tumor may resemble a benign basal cell adenoma. This transformation rate is higher in membranous subtype, being upto 28%.
It may be divided on the basis of its morphologic pattern into four subtypes. Histologically, isomorphic cells in nests and interlaced trabecules with a. Basal cell adenoma salivary gland neoplasms parotid neoplasms salivary gland tumors are among the pathologies in the head and neck that may be challenging in diagnosis and treatment. The basal cell adenoma is a benign epithelial tumor predominantly of the parotid gland that has distinctive gross and microscopic features entitling it to a. Basal cell adenoma bca of the salivary gland is a rare neoplasm consists of a monomorphic population of basaloid epithelial cells, and it.
Basal cell adenoma is a rare type of benign salivary gland tumor found most commonly in the parotid gland. Basal cell adenoma, solid variant acta otolaryngol 1998. The patient was a 59yearold japanese man who visited our department in december 2012 with a chief complaint of a mass in the upper lip, which had increased in size over several years. Basic salivary gland pathology 1 basic salivary gland pathology jennifer l.
The malignant transformation of benign salivary gland tumors results in a. Incidence of basal cell adenoma is about 1 to 3 % of salivary gland tumors. The tumor was studied by electron microscopy, and fine structural features included numerous desmosomes, large secretory granules, and. Most bcas are unilateral and round or oval in shape with well. Twentysix of these tumors have been reported in the american literature, the majority occurring in patients 60 years or older. The objective of this study is to pr esent the ct findings of parotid basal cell adenoma. Basal cell adenoma of the parotid gland, cancer 10. Tubulartrabecular type basal cell adenoma of the parotid. We report on a female patient with bca that developed in the right parotid gland in her 50s. Lymphoepithelial cyst lec is also a rare tumorlike lesion and one of true cysts of the parotid gland. We also compare ct findings of basal cell adenoma with those of pleomorphic adenoma, the most common.
Reviewed and approved by a member of the dovemed editorial board first uploaded. Basal cell adenoma of the parotid gland basal cell adenoma of the parotid gland batsakis, john g. Basal cell adenoma of the submandibular gland europe pmc. Destruction of nearby tissue by bca has not been reported. Basal cell adenoma of the parotid gland american cancer society. Bcac is classified as a lowgrade malignancy predominantly affecting parotid and submandibular salivary glands. Basal cell adenoma is a specific type of monomorphic tumor of the salivary glands that closely resembles basal cell lesions of the skin. Case report of basal cell adenocarcinoma of the parotid gland. A large basal cell adenoma extending to the ipsilateral. We describe basal cell adenoma in a young man with emphasis on cytological features. It usually appears as a firm and mobile slowgrowing mass.
The present patient demonstrated a few tumor nests in the fibrous capsule, and her tumor was larger than usual. Basal cell adenoma bca is a rare benign epithelial tumor of the salivary gland, displaying monomorphic basaloid cells without a myxochondroid component. Basal cell adenoma bca is a rare benign tumor arising in salivary gland tissues. Basal cell adenoma bca of the salivary gland is a rare neoplasm consists of a monomorphic population of basaloid epithelial cells, and it accounts for approximately 12 % of all salivary gland tumours. Conclusion basal cell adenoma is a very rare benign parotid tumor. Basal cell adenoma of the lung identified with obstructive.
Basal cell adenomas bcas are rare tumors of the parotid gland. A case of basal cell adenoma of the parotid gland is reported. Congenital basal cell adenoma of the submandibular gland. We describe a case of basal cell adenoma of the parotid gland. Parotid tumours usually arise on one side and bilateral occurrence is very rare, accounting for about 0. In 2005, world health organization defined basal cell adenocarcinoma bcac as an epithelial neoplasm that has cytological characteristics of basal cell adenoma bca, but a morphologic growth pattern indicative of malignancy. We present a rare case of basal cell adenoma arising in the minor salivary gland of the upper lip. The world health organization classifies it as a subtype of salivary gland epithelial tumors usually occurring in the parotid gland, but is far less common than pleomorphic adenomas pas and warthin tumors wts, ranking third in benign parotid tumors. Basal cell adenomas are unique benign salivary gland tumors affecting women over 50 years of age comprising % of all salivary gland tumors. Basal cell adenoma in the parapharyngeal space resected. Basal cell adenocarcinoma of salivary gland is a type of malignant epithelial tumor, commonly affecting the major salivary parotid glands. Salivary gland tumors are rare and constitute about 2 to 6. Pdf basal cell adenoma of the salivary glands is an uncommon type of monomorphous adenoma. Bca appears most frequently in the parotid glands and in adult 24.
A case history is presented to emphasize its occurrence in older men and to discuss its pathological appearance. Basal cell adenoma of the parotid glanda rare entity. We presented a case of tubular bca in the deep lobe of the parotid. We studied 11 cases of basal cell adenoma bca of the parotid gland in which surgery had been performed in the past 12 years to investigate the clinical and pathological characteristics and to compare the diagnosistreatment of bca with those of warthins tumor wt and pleomorphic adenoma pa. Malignant nonbasaloid tumors that arise from basal cell adenoma bca are extremely rare. Bca usually occurs in adult patients, and there is a slight predilection for females. Batsakis, md a single case report of basal cell adenoma of the parotid gland is presented. We report ct and mr findings of three cases with basal cell adenoma occurring in the parotid gland.
Basal cell adenoma bca of the salivary gland is a rare neoplasm consists of a monomorphic population of basaloid epithelial cells, and it accounts for approximately 12 % of all salivary gland tumors. Basal cell adenoma misdiagnosed as an adenoid cystic carcinoma in the parotid gland 315 no evidence of infiltrating margin. Basal cell adenoma is a rare benign epith elial tumor of the salivary gland. Mr features of bca, including diffusionweighted imaging and dynamic contrastenhanced study, have not been previously described. Basal cell adenoma is a rare benign epithelial tumor of the salivary gland, accounting for 12% of all salivary gland epithelial tumors. Basal cell adenoma bca is a rare benign salivary gland tumor, characterized by isomorphic basaloid cells. The use of the terms monomorphic adenoma, basal cell adenoma and canalicular adenoma as applied to salivary gland tumors. Only a few case reports describing mr imaging features of bca have been published. A clinical study on basal cell adenoma of the parotid gland. The aim of this study was to describe and characterize the mr findings of bcas of the parotid gland. Basal cell adenoma versus pleomorphic adenoma of the. The basal cell adenoma is a specific type of adenoma, with a uniform, monomorphous histologic appearance that is dominated by basaloid cells and that does not have the myxochondroid tissue characteristic of mixed tumors. Dr amitha g dept of oral and maxillofacial pathology 2. The basal cell adenoma was first reported as a distinct entity by kleinsasser and klein in 1967.
Variablysized solid nests are streaming from the solid component and are attenuating parts of the capsule. Basal cell adenoma of the parotid gland is infrequently seen and rarely documented in the american literature. The cribriform variant of the basal cell adenoma with capsular invasion shows a focal tonguelike projection into the capsule. Salivary gland tumors constitute about 34% of all head and neck neoplasm.
Basal cell adenoma bca is an exceedingly uncommon benign tumor of the salivary glands and accounts for less than 0. Request pdf basal cell adenoma of the parotid glanda rare entity salivary gland tumors are uncommon and constitute about 2. By the previous who classification 1991, basal cell adenoma bca was recognized as an independent entity among salivary gland tumours. Basal cell adenomas arise almost exclusively in adults, with the average patient age being 57.
Basal cell adenoma of the salivary glands is an uncommon type of monomorphous adenoma. Systematic evaluation of the world health organization classification of salivary gland tumors. Due to prognostic implications, differential diagnosis with basal cell adenocarcinoma, adenoid cystic carcinoma and basaloid squamous cell carcinoma is. The basal cell adenoma is a benign epithelial tumor predominantly of the parotid gland. Basal cell adenoma bca is an uncommon benign salivary gland neoplasm that includes isomorphic basaloid cells. Clinically, they usually present as a painless palpable mass, indistinguishable from other salivary gland tumors, including pleomorphic adenoma, the most. Basal cell adenoma is a benign salivary gland tumor that also primarily occurs in the parotid gland. A the superficial parotid layer of the parotid gland. Basal cell adenoma and lymphoepithelial cyst as recurrent.